Legend

LEGEND DESCRIPTION Legend i.v. is a clear, colorless, low-viscosity, pyrogen-free, preservative-free, sterile solution for injection. It is administered by intravenous or intra-articular injection. Sodium hyaluronate is also known as hyaluronic acid. Legend i.v. is produced using a proprietary Bayer biotechnology process that ensures the product is free of accompanying proteins, toxins, or nucleic acids and maintains consistent quality. Its purity is the basis for its high tolerability. Legend i.v. solution for injection is available in 4-ml vials (40 mg) Each ml contains: Hyaluronic acid ...................................... 10.0 mg Excipient q.s. .......................................... 1 ml Hyaluronic acid is a fundamental component of synovial fluid; It is found in the form of long chains that form a fine mesh acting as a filter or barrier to prevent the passage of certain molecules or cells. Hyaluronic acid is a glycosaminoglycan that can be found as the acid salt or as sodium hyaluronate; It is composed of repeating subunits of D-glucuronic acid and N-acetyl-D-glucosamine linked by glycosidic bonds. Bayer’s exclusive, patented biotechnological production method ensures that this hyaluronic acid is not contaminated by dermatan sulfate, chondroitin sulfate, other glycosaminoglycans, or microbial products. Hyaluronic acid has traditionally been administered directly into the joint to increase viscosity and lubrication, since during inflammatory processes in the joints, the lysosomal enzymes of inflammatory cells break it down; Therefore, intra-articular administration was intended to replenish hyaluronic acid and restore viscosity. Legend i.v. is the only innovative hyaluronic acid that undergoes a molecular weight adjustment during its manufacturing process, allowing for intravenous administration; This unique characteristic prevents the formation of emboli or the trapping of molecules at the tissue level, allowing it to exert its effects systemically and rapidly. Pharmacology Hyaluronic acid is a substance commonly found naturally in connective tissue, skin, the vitreous humor, and the umbilical cord in all mammals. High concentrations of hyaluronic acid are also found in synovial fluid. It also constitutes the major component of the capsule of certain microorganisms. The mechanism of action of sodium hyaluronate in the treatment of degenerative joint disease. Its primary function appears to be the regulation of normal cellular constituents; It exerts an effect on the release of enzymes from cartilage, thereby preventing the degradation of joint integrity. Additionally, it has been recognized to have a powerful anti-inflammatory effect by stabilizing lymphocyte membranes through the inhibition of granulocyte and macrophage migration. Sodium hyaluronate’s high affinity for water—which is not merely bound but is trapped within its three-dimensional structure—is primarily responsible for the well-known high viscosity of synovial fluid. Some recent studies have shown that sodium hyaluronate exerts its lubricating effect primarily on the membrane separating the synovial fluid from the soft tissue (capsule) of the joint, which has a more powerful damping action than the articular surfaces. This is explained by the fact that the molecules of viscous sodium hyaluronate pass directly from the intracellular space of the synovial membrane into the synovial fluid, thus forming a fluid and elastic transition from the capsule to the joint cavity. Box containing two 4-ml vials (40 mg) and two sterile syringes. SLOW intravenous or intra-articular administration. Horses : In healthy horses, in preparation for competitions or for rapid recovery after intense physical activity, 2 to 3 intravenous administrations at 2-week intervals are recommended. Treated horses should be rested from physical activity following administration of Legend i.v. and gradually returned to normal activity